An Introduction to Wet Granulation in Pharmaceutical Manufacturing

Granulation is a critical process for transforming powders into uniform, free-flowing granules, which are then compressed into tablets. At Schematic Engineering Industries, we specialise in advanced granulation solutions that enhance product quality and manufacturing efficiency. This article delves into the intricacies of wet granulation, comparing it with dry granulation, exploring its advantages and disadvantages, and detailing the tablet preparation process.

_{Wet Granulation vs. Dry Granulation: Which is Better?}

The choice between wet and dry granulation depends on the specific requirements of the pharmaceutical product. Wet granulation involves adding a liquid solution to powders to form granules, while dry granulation compresses powders without liquids. Wet granulation is preferred when the ingredients are not sensitive to moisture and heat, offering better uniformity and compressibility. Dry granulation is suitable for moisture-sensitive compounds, offering a simpler process and shorter production times.

_{Duration of Wet Granulation}

The wet granulation process can take several hours to complete, depending on the specific formulation and equipment used. It involves mixing powders with a granulating fluid, massing the mixture, drying the granules, and milling them to the desired size.

_{Advantages and Disadvantages of Wet Granulation}

Advantages:

• Improves flow properties and compressibility of the powder.
• Enhances uniformity of the active ingredient distribution.
• Suitable for high-dose drugs and those with poor flow properties.

Disadvantages:

• Time-consuming and more complex than dry granulation.
• Requires additional equipment and energy for drying.
• Not suitable for moisture-sensitive or thermally unstable drugs.

_{Tablet Preparation by Wet Granulation}

1. Mixing: Combine the active pharmaceutical ingredient (API) with excipients.
2. Granulating: Add a granulating liquid to the powder mix to form a wet mass.
3. Screening: Pass the wet mass through a screen to produce granules.
4. Drying: Dry the granules using a fluid bed dryer or tray dryer.
5. Milling: Mill the dried granules to a uniform size.
6. Blending: Blend the granules with lubricants and disintegrants.
7. Compression: Compress the blend into tablets using a tablet press.

_{Schematic's Granulation Line Isolators}

Schematic Engineering Industries offers advanced granulation line isolators, supporting both wet and dry granulation processes. Our equipment includes granulators, fluid bed dryers, mills, and blenders, designed for safe and efficient pharmaceutical manufacturing. Schematic provides integrated solutions, ensuring compliance with stringent regulatory standards and optimal performance.

For more information on Schematic's products, contact our expert team here.